Used in T2DM Patients uncontrolled on Dual Therapy
Glimepiride (Sulfonylurea): Stimulates pancreatic β-cells → ↑ insulin secretion (insulin secretagogue).
Metformin (Biguanide): ↓ Hepatic gluconeogenesis + ↑ insulin sensitivity in peripheral tissues (muscle, fat).
Pioglitazone (Thiazolidinedione): Activates PPAR-γ receptors → ↑ insulin sensitivity in adipose & muscle, redistributes fat to less lipotoxic depots.
Glimepiride 2mg + Metformin ER 500mg+Pioglitazone 15mg
Used in T2DM Patients uncontrolled on Dual Therapy
Combination provides a synergistic triple mechanism—Glimepiride boosts insulin secretion, Metformin suppresses hepatic glucose output, and Pioglitazone improves insulin sensitivity—offering comprehensive glycemic control
Dosage: Available in oral tablet form. Once Daily
